What are Orthobiologics?
Orthobiologics are natural substances such as cells, tissue, blood components and growth factors that are harnessed to aid in the treatment of orthopaedic injuries or conditions. They may be used to replace lost tissue, stimulate regeneration and healing, reduce pain and inflammation and improve joint function.
Orthobiologics may be obtained from your own body or from a donor. They may be administered in the form of injections or may require a surgical procedure. They may be used alone as conservative treatment or following orthopaedic surgery to enhance results.
What are the Conditions Treated by Orthobiologics?
Orthobiologics can be used to treat:
- Articular cartilage injuries
- Early osteoarthritis
- Ligament injuries
- Tendon injuries
When are Orthobiologics recommended?
Orthobiologics are recommended when rest, medications and physical therapy do not relieve symptoms and joint replacement surgery is not indicated. It may also be recommended following spine surgery.
Types of Orthobiologics
The different types of orthobiologics include:
Platelet rich plasma (PRP): PRP is obtained from your own blood after it has been processed to concentrate platelets and certain white blood cells that enhance healing and reduce inflammation. PRP may be injected directly into the damaged tissue during an outpatient procedure or following repair surgery.
Bone marrow aspiration concentrate (BMAC): BMAC is obtained after processing bone marrow that is removed from your pelvic bone. BMAC is rich in stem cells, which produce proteins and growth factors necessary for healing and reducing inflammation.
Adipose tissue: Adipose tissue or fat cells have remarkable healing and regenerative properties. It is typically obtained from your waist, processed to remove impurities and inflammatory components, and then injected at the site of injury.
Amniotic products: Amniotic tissue products such as amniotic membrane and amniotic fluid can reduce inflammation and promote healing in tissues due to their cellular content and presence of hyaluronic acid. Amniotic tissues support the foetus in the womb. They are obtained from a consenting healthy donor following an elective caesarean section delivery. These products are carefully screened before use. They are available as injections or patches.
Cartilage transplantation: Cartilage transplantation is a procedure to restore articular cartilage in a joint by transplanting it from another region of your body or using cartilage from a donor. Articular cartilage is the white tissue lining the ends of bones that form joints. It acts as cushioning material and helps in smooth gliding of bones during movement. Articular cartilage damaged by injury or early osteoarthritis is replaced during this procedure.
Our blood consists of a liquid component known as plasma. It also consists of three main solid components that include the red blood cells (RBCs), white blood cells (WBCs), and platelets. Platelets play an important role in forming blood clots. They also consist of special proteins, known as growth factors, which help with our body’s healing process. Platelet-rich plasma or PRP is a high concentration of platelets and plasma. A normal blood specimen contains only 6% platelets, while platelet-rich plasma contains 94% of platelets and 5 to 10 times the concentration of growth factors found in normal blood, thus greater healing properties.
N-stride injection is used to treat knee osteoarthritis. It is prepared from blood extracted from your body and is rich in anabolic growth factors, special proteins involved in the body’s healing process and anti-inﬂammatory proteins responsible for suppressing inflammation in your knee joints.